Devices and methods for endoluminal plication

A method for gastric volume reduction, comprising:

• advancing a tissue acquisition and fixation device endoscopically through an esophagus and into a stomach;
• manipulating the tissue acquisition and fixation device within the stomach to form a first fold of tissue on an interior surface of an anterior wall of the stomach;
• manipulating the tissue acquisition and fixation device within the stomach to form a second fold of tissue on an interior surface of a posterior wall of the stomach, wherein the second fold is not attached to the first fold;
• wherein manipulating the tissue acquisition and fixation device comprises positioning first and second jaws of the tissue acquisition and fixation device to extend substantiall parallel to the anterior wall of the stomach, pivoting the first and second jaws toward an open position, and drawing tissue through the first and second jaws using a tissue acquisition member to form the first and second folds.