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US 9,173,607 B2Granted
Polymer membranes for continuous analyte sensors
AssigneeDexCom, Inc.
InventorsRobert Boock, Monica Rixman Swinney, Huashi Zhang, Michael J. Estes, Kristina Lawrence
Life of this patent
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Abstract
Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.
Claims20
A device for continuous measurement of an analyte concentration, the device comprising:
- a sensing mechanism configured to continuously measure a signal associated with an analyte concentration in a host;
- and
- a membrane located over the sensing mechanism;
- wherein the device is configured to provide, at analyte concentrations of from about 40 mg/dL to about 80 mg/dL, a level of accuracy of a mean absolute relative difference of no more than about 10% over a sensor session of at least about 3 days, wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of blood;
- and
- wherein the device is configured to provide, at analyte concentrations of from about 40 mg/dL to about 400 mg/dL, a level of accuracy of a mean absolute relative difference of no more than about 10% over the sensor session, wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of blood.
3 more elements
A device for continuous measurement of an analyte concentration, the device comprising:
- a sensing mechanism configured to continuously measure a signal associated with an analyte concentration in a host;
- and
- a membrane located over the sensing mechanism;
- wherein, over a sensor session of at least about 3 days, the device is configured to:
- provide a level of accuracy corresponding to a first mean absolute relative difference value at analyte concentrations of from about 40 mg/dL to about 80 mg/dL, wherein one or more reference measurements associated with calculation of the first mean absolute relative difference are determined by analysis of blood;
- and
- provide a level of accuracy corresponding to a second mean absolute relative difference value at analyte concentrations of from about 40 mg/dL to about 400 mg/dL, wherein one or more reference measurements associated with calculation of the second mean absolute relative difference are determined by analysis of blood;
- and
- wherein the first mean absolute relative difference value is less than or about equal to the second mean absolute relative difference value.
6 more elements
A system for continuous measurement of an analyte concentration, the system comprising:
- a sensor comprising a sensing region configured to continuously produce sensor data associated with an analyte concentration in a host, wherein the sensor further comprises a membrane located over the sensing region;
- a processor configured to process continuous sensor data;
- and
- a user interface configured to display information associated with continuous sensor data;
- wherein the sensor is configured to provide, at analyte concentrations of from about 40 mg/dL to about 80 mg/dL, a level of accuracy of a mean absolute relative difference of no more than about 10% over a sensor session of at least about 3 days, wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of blood;
- and
- wherein the sensor is configured to provide, at analyte concentrations of from about 40 mg/dL and about 400 mg/dL, a level of accuracy of a mean absolute relative difference of no more than about 10% over the sensor session, wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of blood.
4 more elements
A system for continuous measurement of an analyte concentration, the system comprising:
- a sensor comprising a sensing mechanism configured to continuously measure a signal associated with an analyte concentration in a host, wherein the sensor further comprises a membrane located over the sensing mechanism;
- a processor configured to process continuous sensor data;
- and
- a user interface configured to display information associated with continuous sensor data;
- wherein, over a sensor session of at least about 3 days, the system is configured to:
- provide a level of accuracy corresponding to a first mean absolute relative difference value at analyte concentrations of from about 40 mg/dL to about 80 mg/dL, wherein one or more reference measurements associated with calculation of the first mean absolute relative difference are determined by analysis of blood;
- and
- provide a level of accuracy corresponding to a second mean absolute relative difference value at analyte concentrations of from about 40 mg/dL to about 400 mg/dL, wherein one or more reference measurements associated with calculation of the second mean absolute relative difference are determined by analysis of blood;
- and
- wherein the first mean absolute relative difference value is less than or about equal to the second mean absolute relative difference value.
7 more elements
Dependencies are inferred from the claim text.