Polymer membranes for continuous analyte sensors
AssigneeDexCom, Inc.
InventorsRobert Boock, Monica Rixman Swinney, Huashi Zhang, Michael J. Estes, Kristina Lawrence
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Abstract
Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.
Claims14
A system for measurement of an analyte concentration, the system comprising:
- an implantable sensor comprising a sensing region configured to continuously produce in vivo sensor data indicative of an analyte concentration in a host, wherein the sensor further comprises a membrane located over the sensing region, wherein the membrane comprises a layer configured to reduce a flux of the analyte therethrough, wherein the layer comprises a material that is a polymer produced by a reaction of an isocyanate;
- a processor configured to process sensor data;
- and
- a user interface configured to display information corresponding to continuous sensor data;
- wherein the sensor is configured to provide, at analyte concentrations of from 40 mg/dL to 400 mg/dL, a level of accuracy corresponding to a mean absolute relative difference of less than 10% over a sensor session length of from 3 to 7 days, wherein one or more reference measurements used to calculate the mean absolute relative difference are determined by analysis of blood.
A system for measurement of an analyte concentration, the system comprising:
- an implantable sensor comprising a sensing region configured to continuously produce in vivo sensor data indicative of an analyte concentration in a host, wherein the sensor further comprises a membrane located over the sensing region, wherein the membrane comprises a layer configured to reduce a flux of the analyte therethrough, wherein the layer comprises a material that is a polymer produced by a reaction of an isocyanate;
- a processor configured to process sensor data;
- and
- a user interface configured to display information corresponding to continuous sensor data;
- wherein the sensor is configured to provide, at analyte concentrations of from 40 mg/dL to 400 mg/dL, a level of accuracy corresponding to a mean absolute relative difference of from 6.8% to 9.6% over a sensor session length of from 3 to 7 days, wherein one or more reference measurements used to calculate the mean absolute relative difference are determined by analysis of blood.
Dependencies are inferred from the claim text.