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US 9,173,558 B2Granted
Method for calculating tear film lipid and aqueous layer thicknesses and corneal surface refractive index from interferometry data
AssigneeAbbott Medical Optics Inc.
InventorsStanley Huth, Denise Tran, Huawei Zhao, Alkan Gulses
Life of this patent
Estimating the term…
Abstract
Disclosed herein is a method of calculating tear film lipid and aqueous layer thicknesses and/or corneal surface refractive index from interferometry data obtained from simultaneous measurements of the aqueous and lipid layers of the tear film along with a measurement of the corneal surface reflectance.
Claims20
A method of evaluating an ocular environment of a patient comprising:
- (a) selecting the patient;
- (b) aligning an eye of the patient with light originating from a light source;
- (c) measuring light reflectance from the eye;
- (d) fitting the light reflectance to a mathematical construct based upon a characteristic mathematical matrix of a thin film stack comprising in sequence from top to bottom:
- air as a boundary, a tear film lipid layer, a tear film aqueous layer and a contact lens as a semi-infinite substrate;
- and
- (e) determining a parameter selected from the group consisting of lipid layer thickness, aqueous layer thickness and contact lens surface refractive index.
4 more elements
A method of evaluating an ocular environment of a patient comprising the steps of:
- (a) selecting the patient;
- (b) aligning an eye of the patient with light originating from a light source;
- (c) measuring light reflectance of the eye;
- (d) fitting the light reflectance to a mathematical construct based upon a characteristic mathematical matrix of a thin film stack comprising in sequence from top to bottom:
- air as a boundary, a tear film lipid layer, a tear film aqueous layer and a contact lens as a semi-infinite substrate;
- (e) determining a first parameter selected from the group consisting of lipid layer thickness, aqueous layer thickness and contact lens surface refractive index;
- and
- (f) comparing the first parameter with known parameters for patients with known tear film or contact lens surface characteristics.
5 more elements
A method of evaluating an ocular environment of a patient comprising the steps of:
- (a) selecting the patient;
- (b) aligning an eye of the patient with light originating from a light source;
- (c) measuring light reflectance from the eye;
- (d) fitting the light reflectance to a mathematical construct based upon a characteristic mathematical matrix of a thin film stack comprising in sequence from top to bottom:
- air as a boundary, a tear film lipid layer, a tear film aqueous layer and a contact lens as a semi-infinite substrate;
- and
- (e) calculating at least one of (a) tear film lipid layer thickness, (b) tear film aqueous layer thicknesses, and (c) refractive index of the contact lens surface of the patient using the mathematical construct.
4 more elements
Dependencies are inferred from the claim text.