Back to results
US 9,169,317 B2Granted
Method of altering the binding specificity of plasma proteins by oxidation-reduction
AssigneeRedox-Reactive Reagents LLC
InventorJohn A. McIntyre
Life of this patent
Estimating the term…
Abstract
The binding specificity of at least one plasma protein suspended or dissolved in a liquid medium is altered by exposing the protein to an oxidizing agent or an electric current sufficient to alter its binding specificity. A masked protein such as an autoantibody can be recovered from blood or blood products or extracts by oxidizing the protein to change its binding specificity.
Claims5
A method comprising the steps of
- providing a composition comprising at least antibody suspended or dissolved in a liquid medium, the at least one antibody having a binding specificity that can be altered by a change in its redox state, and then
- exposing the composition to an oxidizing agent or DC current sufficient to reversibly alter the binding specificity of the at least one antibody.
Dependencies are inferred from the claim text.