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US 9,169,190 B2Granted
Methods for making retinoids and uses thereof
AssigneeThe UAB Research Foundation
InventorsWayne J. Brouillette, Donald D. Muccio, Venkatram Reddy Atigadda, John M. Ruppert, Susan M. Lobo Ruppert
Life of this patent
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Abstract
Described herein are methods for making retinoids. Also described herein are retinoids and methods of use thereof.
Claims11
A compound having the formula XXX
- wherein R1 is a C5-C15 branched or straight chain alkyl group;
- R2 is hydrogen, a C1-C15 branched or straight chain alkyl group, an aryl group, an aralkyl group, or a cycloalkyl group;
- and
- R3 is one or more groups independently selected from the group consisting of hydrogen, a C1-C15 branched or straight chain alkyl group, an aryl group, an aralkyl group, and a cycloalkyl group;
- R6 and R7 are, independently, hydrogen, a C1-C15 branched or straight chain alkyl group, or a cycloalkyl group;
- R11 is hydrogen or a C1-C15 branched or straight chain alkyl group;
- and
- n is from 0 to 3,
- wherein one or more carbon atoms in the ring in formula XXX can optionally be replaced with a heteroatom,
- or the pharmaceutically-acceptable salt or ester thereof.
7 more elements
A compound having the formula XXXII
- wherein R1 and R2 are independently selected from the group consisting of hydrogen, a C1-C15 branched or straight chain alkyl group, an aryl group, an aralkyl group, and a cycloalkyl group, or R1 and R2 collectively form a fused aryl group;
- R3 is one or more groups independently selected from the group consisting of hydrogen, a C1-C15 branched or straight chain alkyl group, an aryl group, an aralkyl group, and a cycloalkyl group;
- R4, R6, and R7 are, independently, hydrogen, a C1-C15 branched or straight chain alkyl group, or a cycloalkyl group;
- R10 and R11 are, independently, hydrogen or a C1-C15 branched or straight chain alkyl group;
- and
- n is from 0 to 3,
- wherein one or more carbon atoms in the ring in formula XXXII can optionally be replaced with a heteroatom,
- or the pharmaceutically-acceptable salt or ester thereof,
- wherein R4 and R10 are not both a methyl group.
6 more elements
Dependencies are inferred from the claim text.