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US 9,169,182 B2Granted
Chrysophaentin analogs that inhibit FtsZ protein
AssigneesThe United States of America, as represented by the Secretary, Department of Health and Human Services, University of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsCarole A. Bewley, Peter Wipf
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Abstract
Embodiments of antimicrobial chrysophaentin compounds, pharmaceutical compositions including the chrysophaentin compounds, methods for using the chrysophaentin compounds, and methods for synthesizing the chrysophaentin compounds are disclosed. Certain embodiments of the chrysophaentin compounds inhibit FtsZ protein, thereby inhibiting the growth of clinically relevant bacteria, including drug-resistant strains.
Claims17
A compound according to formula IX,
- wherein each R1 is independently hydroxyl, C1-10alkoxy, or C1-10alkyl ester;
- R2, and R4 independently are halogen;
- R5 is independently hydrogen, hydroxy, or halogen;
- and R9, R10, and R11 independently are hydrogen, hydroxyl, C1-10 alkoxy, or —B(OH)2.
1 more element
Dependencies are inferred from the claim text.