Medicament blister
AssigneeBoehringer Ingelheim International GmbH
InventorsBurkhard Metzger, Johannes Geser, Hubert Hoelz
Life of this patent
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Abstract
The present invention relates to medicament blisters for powder inhalers. The blisters according to the invention contain an inhalable powder comprising a medicament. The blisters are characterized by a reduced permeability for water vapor, which is achieved by decreasing the height of the sealing lacquer layer.
Claims19
A blister for accommodating one or more individual doses of a medicament formulation, in which each individual dose is present in a completely closed cavity, containing
- a base element with at least one cavity open to at least one side,
- a sealing film that closes the at least one opening of the at least one cavity to form a hollow space with the medicament formulation embedded therein, and
- a sealing lacquer layer lying between the base element and sealing film,
- wherein a surface area of a relative, outwardly oriented surface of the sealing lacquer layer accounts for up to 0.035% of a surface area of an outwardly oriented surface of a seam including the base element, the sealing film, and the sealing lacquer layer of the closed blister.
A blister for accommodating one or more individual doses of a medicament formulation, in which each individual dose is present in a completely closed cavity, containing
- a base element with at least one cavity open to at least one side,
- a sealing film that closes the at least one opening of the at least one cavity to form a hollow space with the medicament formulation embedded therein, and
- a sealing lacquer layer lying between the base element and the sealing film,
- wherein a water vapour permeability through the sealing lacquer layer in a stationary equilibrium state is less than or equal to 320 μg/mm2, measured at a relative atmospheric humidity in the cavity of 16% and an atmospheric humidity of external surroundings of the blister of 75%, at a temperature of 40° C., and over a period of 6 months.
Dependencies are inferred from the claim text.