Bone/collagen composites and uses thereof
AssigneeWarsaw Orthopedic, Inc.
InventorsSherry Hsiu-Ying Wang, Michael Jaffe, Lawrence A. Shimp, Nels J. Lauritzen, Charles M. Schiff
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Abstract
A composition includes bone and collagen, wherein the collagen has been acid treated, and cross-linked via dehydrothermal treatment or by a cross-linking agent (e.g., a citric acid derivative) under a compressive force of at least approximately 40 MPa.
Claims18
A composition comprising:
- approximately 10% to approximately 50% by weight of pressure treated collagen, wherein the pressure treated collagen is cross-linked using a citric acid derivative under a compressive force of at least approximately 40 MPa, and the composition is load bearing and has a wet compressive strength of from about 7 MPa to about 52 MPa;
- harvested bone including a linker configured to facilitate interactions with the pressure treated collagen;
- and
- the citric acid derivative.
A composition comprising bone particles and approximately 10% to approximately 50% by weight of pressure treated collagen, the bone particles comprising a linker configured to facilitate interactions with the pressure treated collagen, the composition being load bearing and having a wet compressive strength of from about 7 MPa to about 52 MPa, wherein the composition is prepared by adding bone particles to a dispersion of pressure treated collagen at an acidic pH ranging from approximately 3 to approximately 6;
- applying a compressive force at least approximately 40 MPa;
- and cross-linking the pressure treated collagen using a citric acid derivative, the composition further comprising the citric acid derivative.
Dependencies are inferred from the claim text.