Collagen materials and methods for obtaining same
AssigneeBiom'up
InventorsChristian Gagnieu, Patricia Forest, Sylvain Picot
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Abstract
The invention relates to novel collagen materials and, specifically, collagen membranes, tubes and threads. Said materials combine enhanced properties of resilience and strength. The invention also relates to a method for preparing collagen materials using acid fibrous collagen comprising coagulation and, optionally, cross-linking of the collagen in the presence of ammonia gas.
Claims10
A method for preparing a collagen material comprising the following steps, performed in the following order:
- a) preparing an aqueous solution of native or denatured collagen, wherein the aqueous collagen solution is at an acidic pH,
- b) adding an oxidized polysaccharide comprising an aldehyde group as a cross-linking agent that is non-reactive at acidic pH to the aqueous collagen solution of step a),
- c) molding or casting the aqueous collagen solution of step b),
- d) coagulating and cross-linking the molded or casted aqueous collagen solution of step c) by treating the molded or casted aqueous collagen solution with ammonia gas, wherein cross-linking occurs at least partially concomitantly with the coagulation of the collagen, and
- e) removing excess ammonia and obtaining said collagen material by drying.
A method for preparing a fabric-reinforced collagen membrane comprising the following steps, performed in the following order:
- a) preparing an aqueous solution of native or denatured collagen, wherein the aqueous collagen solution is at an acidic pH,
- b) adding an oxidized polysaccharide comprising an aldehyde group as a cross-linking agent that is non-reactive at acidic pH to the aqueous collagen solution of step a),
- c) molding or casting the aqueous collagen solution of step b) and depositing a textile on the molded or casted aqueous collagen solution,
- d) coagulating and cross-linking the molded or casted aqueous collagen solution, which contains the cross-linking agent of step c), by treating the molded or casted aqueous collagen solution with ammonia gas, wherein cross-linking occurs at least partially concomitantly with the coagulation of the collagen, and
- e) removing excess ammonia and obtaining said fabric-reinforced collagen membrane by drying.
Dependencies are inferred from the claim text.