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US 9,168,307 B2Granted
Mitochondrial-targeted cationic nanoparticles comprising CaMKII inhibitors and uses thereof for treating and preventing diseases and disorders associated with CaMKII activity
AssigneeUniversity of Iowa Research Foundation
InventorsMark E. Anderson, Mei-ling A. Joiner, Aliasger K. Salem, Amaraporn Wongrakpanich, Frederick E. Domann, Duane D. Hall, Olha M. Koval, Douglas R. Spitz
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Abstract
Disclosed are compositions and methods for treating or preventing diseases or disorders associated with mitochondrial CaMKII activity.
Claims11
Cationic biodegradable nanoparticles comprising:
- (a) a mixture of polylactic-co-glycolic acid (PLGA) and polyamidoamine (PAMAM) dendrimers at a ratio between 6:1 and 2:1 by mass, wherein the nanoparticles have a zeta-potential between about 5-45 mV;
- (b) a CaMKII inhibitor;
- and
- (c) a mitochondrial location sequence (MLS) peptide conjugated to the nanoparticles.
1 more element
Dependencies are inferred from the claim text.