Intravaginal delivery system
AssigneeUniversiteit Gent
InventorsJean Paul Remon, Chris Vervaet, Hans Verstraelen, Marleen Temmerman
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Abstract
The present invention in general relates to an intravaginal delivery system as well as uses thereof and methods for manufacturing and use of the same. In particular the present invention relates to an intravaginal delivery system for the controlled release of one or more organic acids, such as lactic acid; said intravaginal delivery system being characterized in that it comprises a combination of ethylene vinyl acetate (EVA) copolymers and carboxylic polymers, such as for example methacrylic acid-methacrylic ester copolymers.
Claims16
A controlled release intravaginal delivery system for controlled release of one or more liquid carboxylic acids with a pKa of less than 6, the controlled release intravaginal delivery system comprising:
- the one or more liquid carboxylic acids with a pKa of less than 6;
- and
- a combination of one or more ethylene vinyl acetate (EVA) copolymers and one or more carboxylic non-cationic polymers, wherein the one or more carboxylic non-cationic polymers are selected from the group consisting of methacrylic acid copolymers, cellulose acetate phthalates (CAP), acrylic acid copolymers, alginates, hypromellose acetate succinates (HPMCAS), and copolymers or mixtures thereof, and wherein the controlled release intravaginal delivery system controllably releases the one or more liquid carboxylic acids with a pKa of less than 6 therefrom upon administration thereof.
A controlled release intravaginal delivery system for controlled release of one or more liquid carboxylic acids with a pKa of less than 6, the controlled release intravaginal delivery system comprising:
- about 1-20% wt of the one or more liquid carboxylic acids with a pKa of less than 6 selected from the group consisting of lactic acid and acetic acid;
- and
- a combination of about 65-80% wt of one or more ethylene vinyl acetate (EVA) copolymers and about 10-50% wt of one or more carboxylic acids selected from the group consisting of methacrylic acid copolymers, methacrylic ester copolymers, and cellulose acetate phthalates (CAP), wherein the controlled release intravaginal delivery system controllably releases the one or more liquid carboxylic acids with a pKa of less than 6 therefrom upon administration thereof.
Dependencies are inferred from the claim text.