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US 9,168,296 B2Granted
Detection and treatment of autoimmune disorders
AssigneeSeattle Children's Hospital
InventorsNeelufar Mozaffarian, Anne M. Stevens
Life of this patent
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Abstract
Disclosed herein are methods of treatment of autoimmune diseases such as systemic lupus erythematosus (SLE) as well as clinical assays for detection of autoimmune disease activity in patients utilizing a PD1 ligand.
Claims26
A method of diagnosing rheumatoid arthritis (RA) in a human individual suspected of having RA, comprising:
- determining the PD-L1 level in a blood sample obtained from said individual, by contacting said blood sample with a detectably labeled antibody specific for PD-L1;
- comparing the PD-L1 level of the individual suspected of having RA to a reference PD-L1 level, wherein said reference PD-L1 level is derived from the PD-L1 level in one or more individuals that do not have RA;
- and
- diagnosing said individual suspected of having RA as having RA when the PD-L1 level is less than said reference PD-L1 level or identifying said individual as not having RA when the PD-L1 level is not less than said reference PD-L1 level.
1 more element
A method of diagnosing systemic lupus erythematosus (SLE) in a human individual suspected of having SLE, comprising:
- determining the PD-L1 level in a blood sample obtained from said individual, by contacting said blood sample with a detectably labeled antibody specific for PD-L1;
- comparing the PD-L1 level of the individual suspected of having SLE to a reference PD-L1 level, wherein said reference PD-L1 level is derived from the PD-L1 level in one or more individuals that do not have SLE;
- and
- diagnosing said individual suspected of having SLE as having SLE when the PD-L1 level is less than said reference PD-L1 level or identifying said individual as not having SLE when the PD-L1 level is not less than said reference PD-L1 level.
1 more element
Dependencies are inferred from the claim text.