Product and process for mucus viscosity normalization
AssigneeOrpro Therapeutics, Inc.
InventorPeter B. Heifetz
Life of this patent
Estimating the term…
Abstract
Disclosed are compositions and methods for decreasing the viscosity and/or cohesiveness of and/or increasing the liquefaction of excessively or abnormally viscous or cohesive mucus or sputum. The composition contains a protein or peptide containing a thioredoxin monocysteinic active site in a reduced state and optionally further contains a reducing system.
Claims17
A method to decrease viscoelasticity of mucus or sputum in a patient that has excessively viscous or cohesive mucus or sputum, comprising contacting the mucus or sputum of the patient with a composition comprising a protein or peptide containing a thioredoxin monocysteinic active site in a reduced state effective to decrease the viscoelasticity of the mucus or sputum as compared to prior to the step of contacting, wherein the thioredoxin monocysteinic active site comprises an amino acid sequence selected from the group consisting of C-X-X-S (SEQ ID NO:24), C-X-X-X (SEQ ID NO:
- 17), X-C-X-X-X-X (SEQ ID NO:
- 19), X-C-G-P-X-X (SEQ ID NO:
- 21), W-C-G-P-X-K (SEQ ID NO:
- 23), X-C-X-X-S-X (SEQ ID NO:
- 25), X-C-G-P-S-X (SEQ ID NO:
- 26), and W-C-G-P-S-K (SEQ ID NO:
- 27), wherein the C residue is in a reduced state, and wherein the X residues are any amino acid residue other than cysteine.
Dependencies are inferred from the claim text.