US 9,168,270 B2Granted

Water-insoluble, iron-containing mixed metal, granular material

AssigneeOpko Ireland Global Holdings, Ltd.

InventorsRuth Diane Pennel, Maurice Sydney Newton, James David Morrison, Alexis John Toft, Nigel Peter Rhodes

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Abstract

There is provided a granular material comprising (i) at least 50% by weight based on the weight of the granular material of solid water-insoluble mixed metal compound capable of binding phosphate of formula (I): MII1-xMIIIx(OH)2An-y.ZH2O (I) where MII is at least one of magnesium, calcium, lanthanum and cerium; MIII is at least iron(III); An- is at least one n-valent anion; x=Σny; 0<x≦0.67, 0<y≦1, and 0≦z<10; (ii) from 3 to 12% by weight based on the weight of the granular material of non-chemically bound water, and (iii) no greater than 47% by weight based on the weight of the granular material of excipient.

Claims18

Dependent claims

A dried granular material comprising granules, each granule comprising a mixture of

(i) at least 50% by weight based on the weight of the granule of solid water-insoluble inorganic mixed metal compound capable of binding phosphate and which contains iron (III) and at least one of magnesium, calcium, lanthanum or cerium, wherein the mixed metal compound is not a hydrothermally-treated compound,
(ii) from 3 to 10% by weight based on the weight of the granule of non-chemically bound water, and
(iii) an excipient, present in an amount no greater than 47% by weight based on the weight of the granule, wherein at least 50% by weight of the granules of the granular material have a diameter of from 106 micrometers to 1180 micrometers.

Dependencies are inferred from the claim text.

Facts

Application: 12/162,914Filed 30 Jan 2007
Priority: GB 0601899.831 Jan 2006
Published: US 2009/0317459 A124 Dec 2009
Granted: 27 Oct 2015
Term ends: Not estimatedThe source records don’t support an estimate.

Classification15 codes

A61K 33/06
Medicinal preparations containing inorganic active ingredients: aluminium, calcium or magnesium; Compounds thereof , e.g. clay
A61K 9/16
Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles: agglomerates;…
A61K 9/1611
Excipients; Inactive ingredients: inorganic compounds
A61K 9/1635
Organic macromolecular compounds: obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, polyacrylates