Saponins and chromans derivatives mixture compositions against leishmaniasis, Trypanosomiasis americana, malaria, Trypanosomiasis africana and Fasciola hepatica

A composition comprising:

• chroman derivatives of formula 1,
• in a range of 10%-80% by weight of the composition and saponins of formula 2:
• having R selected from the group consisting of:
• 1A, 1B and 1C, in a range of 20%-90% by weight of the composition wherein:
• X represents O, NH, S, S═O, S(O)2, or CH2 and may or may not have a double bond in the position indicated by the figure as a dashed line,
• R1 represent phenyl, naphthyl, aromatic or non aromatic 5-6 membered hetero ring containing at least one of:
• 1-2 N atoms, 0-1 O atoms and 0-1 S atoms, mono or di substituted with substituent selected from the group consisting of:
• OH, CHO, OCH3, NO2, NH2, NHCOCH3, COOH, COOCH3, CH2OH, CN, halogen, C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy or C1-C6 halothioalkyl,
• R2, R3, R4, R5, R6 and R7 independently represent H, OH, CHO, OCH3, NO2, NH2, NHCOCH3, COOH, COOCH3, CH2OH, CN, halogen, C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy or C1-C6 halothioalkyl, —O—S(═O)—R8, N(R9) SO2R10, benzyl, phenyl,
• R8═C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy or C1-C6 halothioalkyl, and
• R9 and R10 are C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 haloalkoxy or C1-C6 halothioalkyl, un substituted or mono or di substituted phenyl or pyridyl, with substituent selected from the group consisting of:
• H, OH, CHO, OCH3, NO2, NH2, NHCOCH3, COOH, COOCH3, CH2OH, CN, halogen, C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy or C1-C6 halothioalkyl, wherein the compounds are individual isomers, mixtures of isomers, tautomeric mixtures including syn or anti, cis or trans or R or S forms.