Estriol therapy for multiple sclerosis and other autoimmune diseases
AssigneeThe Regents of the University of California
InventorRhonda R. Voskuhl
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Abstract
The present invention discloses administering steroid hormones to mammals to treat autoimmune related diseases, more particularly, Th1-mediated (cell-mediated) autoimmune diseases including: multiple sclerosis (MS), rheumatoid arthritis (RA), autoimmune thyroiditis and uveitis. Most preferably the invention is used to treat a patient with a therapeutically effective amount of estriol of 8 milligrams once daily via oral administration to treat the symptoms or prevent the onset of multiple sclerosis.
Claims25
A method of treating a human exhibiting at least one clinical sign or symptom of multiple sclerosis, comprising administering estriol orally at about 4 milligrams to about 16 milligrams per day to ameliorate at least one sign or symptom of multiple sclerosis.
A method of treating a patient exhibiting at least one clinical sign or symptom of multiple sclerosis, comprising administering estriol orally at a dose of about 4 milligrams to about 16 milligrams each day and administering a secondary agent, wherein the administration of estriol and the secondary agent ameliorates the clinical sign or symptom.
Dependencies are inferred from the claim text.