Methods and compositions for sleep disorders and other disorders
AssigneeIntra-Cellular Therapries, Inc.
InventorsSharon Mates, Allen Fienberg, Lawrence P. Wennogle
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Abstract
Use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals and pharmaceutical compositions comprising them for the treatment of one or more disorders involving the 5-HT2A, SERT and/or dopamine D2 pathways are disclosed. In addition, the compounds may be combined with other therapeutic agents for the treatment of one or more sleep disorders, depression, psychosis, dyskinesias, and/or Parkinson's disease or any combinations.
Claims20
A pharmaceutical composition in oral unit dose form comprising an amount of 10 mg or less of a Compound of Formula I:
- wherein X is O, —NH or —N(CH3);
- and Y is —O— or —C(O)—, in free or pharmaceutically acceptable salt form, in combination or association with a pharmaceutically acceptable diluent or carrier, provided that in the case of a salt, the weight is calculated as the free base, where the amount of the Compound of Formula I:
- a) is sufficient to block the 5-HT2A receptor;
- and
- b) either does not block, or minimally blocks the dopamine D2 receptor.
Dependencies are inferred from the claim text.