Substituted dihydropyrazolones for treating cardiovascular and hematological diseases

A method of treatment of a cardiovascular disease, cardiac insufficiency, anemia, a chronic kidney disease or renal insufficiency comprising administering to a human or animal in need thereof an active amount of a compound of formula (I)

• in which
• R1 represents a heteroaryl group of the formula
• wherein
• * denotes the linkage point with the dihydropyrazolone ring
• and
• R4 denotes hydrogen, fluorine, chlorine, bromine, cyano, (C1-C4)-alkyl, trifluoromethyl, hydroxymethyl, (C1-C4)-alkoxy, trifluoromethoxy, hydroxycarbonyl or (C1-C4)-alkoxycarbonyl,
• R2 represents a heteroaryl group of the formula
• wherein
• # denotes the linkage point with the dihydropyrazolone ring
• and
• R6, R6A and R6B are identical or different and independently of one another denote hydrogen or a substituent chosen from the series consisting of fluorine, chlorine, bromine, cyano, (C1-C6)-alkyl, trifluoromethyl, hydroxyl, (C1-C6)-alkoxy, trifluoromethoxy, amino, mono-(C1-C4)-alkylamino, di-(C1-C4)-alkylamino, hydroxycarbonyl, (C1-C4)-alkoxycarbonyl and 4- to 6-membered heterocycloalkyl, wherein
• (C1-C6)-alkyl in its turn can be substituted by hydroxyl, (C1-C4)-alkoxy or amino
• and
• 4- to 6-membered heterocycloalkyl in its turn can be substituted once or twice in an identical or different manner by fluorine, cyano, (C1-C4)-alkyl, trifluoromethyl, hydroxyl, (C1-C4)-alkoxy, oxo, amino, mono-(C1-C4)-alkylamino, di-(C1-C4)-alkylamino, hydroxycarbonyl and/or (C1-C4)-alkoxycarbonyl,
• and
• R3 represents hydrogen,
• and their salts, solvates and solvates of the salts.