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US 9,168,247 B2Granted
Beta carboline derivatives useful in the treatment of proliferative disorders
AssigneesFacultes Universitaires Notre-Dame De La Paix, Universite Libre Bruxelles
InventorsRaphael Frederick, Bernard Masereel, Jeremy Reniers, Johan Wouters, Celine Bruyere, Robert Kiss, Céline Anne Marie Michelle Meinguet, Véronique Emmanuelle Julie Mathieu
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Abstract
The invention provides novel beta-carboline derivatives of formulae (Ia) and (Ib) useful in the treatment of proliferative disorders including cancer, intermediates used in their preparation, processes for preparing the same and uses thereof.
Claims17
A compound of Formulas (Ia), or stereoisomeric forms thereof,
- wherein
- Z1 is —O—,
- R1-L1- is C1-6alkyl optionally substituted with hydroxy, or R1-L1- is benzyl optionally substituted with fluoro;
- R2-L2- is n-propyl or 3-methyl-butyl;
- R3-L3- is C1-6alkyl or benzyl;
- R7 is C1-6alkyl;
- X− is an organic or inorganic anion;
- or pharmaceutically acceptable addition salts, hydrates or solvates thereof.
5 more elements
Dependencies are inferred from the claim text.