Treatment and prevention of cardiovascular disease and thrombosis
AssigneeThe Cleveland Clinic Foundation
InventorsStanley L. Hazen, Bruce Levison, Zeneng Wang
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Abstract
Provided herein are compositions for the treatment and/or prevention of cardiovascular disease (CVD), and methods of application and use thereof. In particular, the present invention provides treatment and/or prevention of cardiovascular disease with compounds that inhibit the production of TMA in the gut, such as 3,3-dimethyl-1-butanol (DMB) or other compounds represented by Formula I or as shown in FIGS. 20-23.
Claims12
A method for reducing TMAO (trimethylamine N-oxide) plasma levels in a subject comprising:
- a) identifying a subject as having increased platelet aggregation and/or elevated TMAO levels, and
- b) administering to said subject a composition comprising trimethylsilyl ethanol under conditions such that plasma TMAO levels are reduced in said subject.
A method of reducing TMAO plasma levels in a subject comprising administering to a subject a composition comprising trimethylsilyl ethanol under conditions such that plasma TMAO levels are reduced in said subject.
Dependencies are inferred from the claim text.