Transdermally absorbable preparation
AssigneeNipro Patch Co., Ltd.
InventorsNaohisa Kawamura, Chie Sugaya
Life of this patent
Estimating the term…
Abstract
Disclosed is a transdermally absorbable preparation, in which an adhesive agent produced by crosslinking at least one copolymer is contained in an adhesive layer and the aging period in the production of the adhesive layer can be shortened. The transdermally absorbable preparation comprises a support and an adhesive layer arranged on the support and containing an adhesive agent and a medicinal component. The transdermally absorbable preparation is characterized in that the adhesive agent comprises a resin mixture comprising 100 parts by mass of a specific acrylic copolymer (A) and 0.1 to 30 parts by mass of a specific acrylic copolymer (B) or 0.05 to 2 part(s) by mass of a polyamine compound, and the adhesive layer additionally contains an organic acid.
Claims13
A transdermally absorbable preparation, having a backing and an adhesive layer which is placed on the backing and which contains an adhesive agent and a medicinal component,
- the adhesive agent comprising a resin mixture comprising 100 parts by mass of an acrylic copolymer (A) and 0.1 to 30 parts by mass of an acrylic copolymer (B), and the adhesive layer further comprising at least one organic acid selected from lactic acid, salicylic acid, succinic acid, thioglycolic acid, maleic acid, malonic acid, adipic acid, benzoic acid, capric acid, sorbic acid, malic acid, and hydrates thereof, and the medicinal component is nicotine or lidocaine, or salts thereof;
- wherein the acrylic copolymer (A) comprises a (meth)acrylic acid alkyl ester as a main monomer component, and comprises 3 to 45% by mass of diacetone acrylamide as a prerequisite monomer component, but does not comprise a free carboxyl group, and has a weight average molecular weight of 1,200,000 to 2,500,000;
- and
- wherein the acrylic copolymer (B) comprises a (meth)acrylic acid alkyl ester as a main monomer component, and comprises a carboxyhydrazide group on side chains, but does not comprise a free carboxyl group, and has a weight average molecular weight of 2,000 to 10,000.
A transdermally absorbable preparation, having a backing and an adhesive layer which is placed on the backing and which contains an adhesive agent and a medicinal component,
- the adhesive agent comprising a resin mixture comprising 100 parts by mass of an acrylic copolymer (A) and 0.1 to 30 parts by mass of an acrylic copolymer (B), and the adhesive layer further comprising 0.05 to 2% by mass of at least one organic acid selected from lactic acid, salicylic acid, succinic acid, thioglycolic acid, maleic acid, malonic acid, adipic acid, benzoic acid, capric acid, sorbic acid, malic acid, and hydrates thereof based on the total mass of the adhesive layer, and the medicinal component is nicotine or lidocaine, or salts thereof;
- wherein the acrylic copolymer (A) comprises a (meth)acrylic acid alkyl ester as a main monomer component, and comprises 3 to 45% by mass of diacetone acrylamide as a prerequisite monomer component, but does not comprise a free carboxyl group, and has a weight average molecular weight of 1,200,000 to 2,500,000;
- and
- wherein the acrylic copolymer (B) comprises a (meth)acrylic acid alkyl ester as a main monomer component, and comprises a carboxyhydrazide group on side chains, but does not comprise a free carboxyl group, and has a weight average molecular weight of 2,000 to 10,000.
Dependencies are inferred from the claim text.