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US 9,168,229 B2Granted
Soft gelatin capsules
AssigneeAltergon S.A.
InventorsGiorgio Zoppetti, Maurizio Marchiorri
Life of this patent
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Abstract
The present invention relates to soft gelatin capsules characterized in that the shell includes a cyclodextrin and in that the filling material contains a liposoluble drug capable of forming a complex with said cyclodextrin for improving the solubility of the active ingredient upon disintegration of the soft gelatin capsule.
Claims5
A soft gelatin capsule consisting of a shell with a gastro-resistant and enteric-soluble coating enclosing a filling material, wherein:
- the filling material consists of a solution of a poorly water-soluble or water-insoluble active ingredient in an oily solvent phase,
- the shell contains a cyclodextrin which is thus maintained separated from the active ingredient in the filling material,
- the shell of the capsule is prepared from a mix containing, by weight:
- from 0.7 to 20% of hydroxypropyl-β-cyclodextrin, or β-cyclodextrin,
- from 20 to 50% by weight of gelatin,
- from 1 to 25% by weight to a plasticizer,
- from 20 to 50% by weight of water,
- where the active ingredient is selected from the group consisting of non-steroid anti-inflammatory drugs having aromatic rings.
5 more elements
Dependencies are inferred from the claim text.