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US 9,168,225 B2Granted
Nano-hybrid delivery system for sequential utilization of passive and active targeting
AssigneeThe Board of Trustees of the University of Illinois
InventorsSeungpyo Hong, Ying Liu
Life of this patent
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Abstract
The present invention features nanohybrid drug delivery composition which combines both passive and active targeting for the prevention and treatment of disease. The composition is shell-encapsulated multivalent polymeric scaffold with a therapeutic agent and targeting agent attached thereto.
Claims10
A nanohybrid drug delivery composition comprising
- a multivalent polymeric scaffold nanocore consisting of branched polyethyleneimine or poly(amidoamine) (PAMAM) dendrimer with a therapeutic agent and a targeting agent covalently attached thereto;
- and
- an outer shell encapsulating the polymeric scaffold nanocore, the therapeutic agent and the targeting agent, wherein the shell consists of poly-(lactic acid-co-glycolic acid), polyethylene glycol-b-polylactide-co-glycolide, polyethylene glycol-b-poly-L-lactic acid, or a unilamellar liposome consisting of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-mPEG-2000, 1,2-dioleoyl-sn-glycero-3-phosphocholine, 1,2-dioleoyl-sn-glycero-3-phospho-(1′-rac-glycerol) and cholesterol.
Dependencies are inferred from the claim text.