Functionalised triblock copolymers and compositions containing such polymers

An amphiphilic triblock copolymer B-A-B, wherein A is a linear poly(ethylene glycol) block having a number average molecular weight (Mn) of between 500 and 3000 Daltons, determined with size exclusion chromatography;

• wherein B are hydrophobic blocks comprising at least two cyclic monomers of glycolide, lactide, ε-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate(1,3-dioxan-2-one), 1,4-dioxepan-2-one (including its dimer 1,5,8,12-tetraoxacyclo-tetradecane-7,14-dione), 1,5-dioxepan-2one, 6,6-dimethyl-1,4-dioxan-2-one, 2,5-diketomorpholine, pivalolactone, chi. -diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, 6,8-dioxabicycloctane-7-one, β-propiolactone, γ-butyrolactone, δ-valerolactone, ε-decalactone, 3-methyl-1,4-dioxane-2,5-dione, 1,4-dioxane-2,5-dione, 2,5-diketo-morpholine, α,α-diethylpropiolactone,γ-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one, 6,8-dioxabicycloctane-7-one, or 5,5-dimethyl-1,3-dioxan-2-one, each B-block having a number average molecular weight (Mn) of between 400 and 3000 Daltons, determined with size exclusion chromatography;
• and wherein 25% to 100% of the polymer hydroxyl end-groups are covalently modified with at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid and wherein the B-blocks comprise monomer combinations comprising glycolide and at least one monomer that is 1,3-dioxan-2-one, 5,5-dimethyl-1,3-dioxan-2-one, 1,4-dioxan-2-one, 1,4-dioxepan-2-one, or 1,5-dioxepan-2-one.

An amphiphilic triblock copolymer B-A-B, wherein A is a linear poly(ethylene glycol) block having a number average molecular weight (Mn) of between 500 and 3000 Daltons, determined with size exclusion chromatography;

• wherein B are hydrophobic blocks comprising at least two cyclic monomers of glycolide, lactide, ε-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate(1,3-dioxan-2-one), 1,4-dioxepan-2-one (including its dimer 1,5,8,12-tetraoxacyclo-tetradecane-7,14-dione), 1,5-dioxepan-2-one, 6,6-dimethyl-1,4-dioxan-2-one, 2,5-diketomorpholine, pivalolactone, chi. -diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, 6,8-dioxabicycloctane-7-one, β-propiolactone, γ-butyrolactone, δ-valerolactone, ε-decalactone, 3-methyl-1,4-dioxane-2,5-dione, 1,4-dioxane-2,5-dione, 2,5-diketo-morpholine, α,α-diethylpropiolactone,γ-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one, 6,8-dioxabicycloctane-7-one, or 5,5-dimethyl-1,3-dioxan-2-one, each B-block having a number average molecular weight (Mn) of between 400 and 3000 Daltons, determined with size exclusion chromatography;
• and wherein 25% to 100% of the polymer hydroxyl end-groups are covalently modified with at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid and wherein the B-blocks comprise monomer combinations comprising lactide and at least one monomer that is 1,3-dioxan-2-one, 5,5-dimethyl-1,3-dioxan-2-one, 1,4-dioxan-2-one, 1,4-dioxepan-2-one, or 1,5-dioxepan-2-one.

An amphiphilic triblock copolymer B-A-B, wherein A is a linear poly(ethylene glycol) block having a number average molecular weight (Mn) of between 500 and 3000 Daltons, determined with size exclusion chromatography;

• wherein B are hydrophobic blocks comprising at least two cyclic monomers of glycolide, lactide, ε-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate(1,3-dioxan-2-one), 1,4-dioxepan-2-one (including its dimer 1,5,8,12-tetraoxacyclo-tetradecane-7,14-dione), 1,5-dioxepan-2-one, 6,6-dimethyl-1,4-dioxan-2-one, 2,5-diketomorpholine, pivalolactone, chi. -diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, 6,8-dioxabicycloctane-7-one, β-propiolactone, γ-butyrolactone, δ-valerolactone, ε-decalactone, 3-methyl-1,4-dioxane-2,5-dione, 1,4-dioxane-2,5-dione, 2,5-diketo-morpholine, α,α-diethylpropiolactone,γ-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one, 6,8-dioxabicycloctane-7-one, or 5,5-dimethyl-1,3-dioxan-2-one, each B-block having a number average molecular weight (Mn) of between 400 and 3000 Daltons, determined with size exclusion chromatography;
• and wherein 25% to 100% of the polymer hydroxyl end-groups are covalently modified with at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid and wherein the B-blocks comprise monomer combinations comprising 1,3-dioxan-2one and at least one monomer that is 5,5-dimethyl-1,3-dioxan-2-one, 1,4-dioxan-2-one, 1,4-dioxepan-2-one, or 1,5-dioxepan-2-one.

An amphiphilic triblock copolymer B-A-B, wherein A is a linear poly(ethylene glycol) block having a number average molecular weight (Mn) of between 500 and 3000 Daltons, determined with size exclusion chromatography;

• wherein B are hydrophobic blocks comprising at least two cyclic monomers of glycolide, lactide ε-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate(1,3-dioxan-2-one), 1,4-dioxepan-2-one (including its dimer 1,5,8,12-tetraoxacyclo-tetradecane-7,14-dione), 1,5-dioxepan-2-one, 6,6-dimethyl-1,4-dioxan-2-one, 2,5-diketomorpholine, pivalolactone, chi. diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, 6,8-dioxabicycloctane-7-one, β-propiolactone, γ-butyrolactone, δ-valerolactone, ε-decalactone, 3-methyl-1,4-dioxane-2,5-dione, 1,4-dioxane -2,5-dione, 2,5-diketomorpholine, α,α-diethylpropiolactone,γ-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one, 6,8-dioxabicycloctane-7-one or 5,5-dimethyl-1,3-dioxan-2-one, each B-block having a number average molecular weight (Mn) of between 400 and 3000 Daltons, determined with size exclusion chromatography;
• and wherein 25% to 100% of the polymer hydroxyl end-groups are covalently modified with at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid and wherein the B-blocks comprise monomer combinations comprising ε-caprolactone and at least one monomer that is 1,3-dioxan-2-one, 5,5-dimethyl-1,3-dioxan-2-one, 1,4-dioxan-2-one, 1,4-dioxepan-2-one, or 1,5-dioxepan-2-one.

An amphiphilic triblock copolymer B-A-B, wherein A is a linear poly(ethylene glycol) block having a number average molecular weight (Mn) of between 500 and 3000 Daltons, determined with size exclusion chromatography;

• wherein B are hydrophobic blocks comprising at least two cyclic monomers of glycolide, lactide, ε-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate(1,3-dioxan-2-one), 1,4-dioxepan-2-one (including its dimer 1,5,8,12-tetraoxacyclo-tetradecane-7,14-dione), 1,5-dioxepan-2-one, 6,6-dimethyl-1,4-dioxan-2-one, 2,5-diketomorpholine, pivalolactone, chi. -diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, 6,8-dioxabicycloctane-7-one, β-propiolactone, γ-butyrolactone, δ-valerolactone, ε-decalactone, 3-methyl-1,4-dioxane-2,5-dione, 1,4-dioxane 2,5-dione, 2,5-diketo-morpholine, α,α-diethylpropiolactone,γ-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one, 6,8-dioxabicycloctane-7-one, or 5,5-dimethyl-1,3-dioxan-2-one, each B-block having a number average molecular weight (Mn) of between 400 and 3000 Daltons, determined with size exclusion chromatography;
• and wherein 25% to 100% of the polymer hydroxyl end-groups are covalently modified with at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid and wherein the B-blocks comprise monomer combinations consisting of between 50 to 100 mol% glycolide;
• and caprolactone as a second monomer.

An amphiphilic triblock copolymer B-A-B, wherein A is a linear poly(ethylene glycol) block having a number average molecular weight (Mn) of between 500 and 3000 Daltons, determined with size exclusion chromatography;

• wherein B are hydrophobic blocks comprising at least two cyclic monomers of glycolide, lactide, ε-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate(1,3-dioxan-2-one), 1,4-dioxepan-2-one (including its dimer 1,5,8,12-tetraoxacyclo-tetradecane-7,14-dione), 1,5-dioxepan-2-one, 6,6-dimethyl-1,4-dioxan-2-one, 2,5-diketomorpholine, pivalolactone, chi. -diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, 6,8-dioxabicycloctane-7-one, β-propiolactone, γ-butyrolactone, δ-valerolactone, ε-decalactone, 3-methyl-1,4-dioxane-2,5-dione, 1,4-dioxane -2,5-dione, 2,5-diketo-morpholine, α,α-diethylpropiolactone,γ-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one, 6,8-dioxabicycloctane-7-one, or 5,5-dimethyl-1,3-dioxan-2-one, each B-block having a number average molecular weight (Mn) of between 400 and 3000 Daltons, determined with size exclusion chromatography;
• and wherein 25% to 100% of the polymer hydroxyl end-groups are covalently modified with at least one acid chloride, anhydride or isocyanate derivative of a C2-C20 fatty acid and wherein the B-blocks comprise monomer combinations comprising between 50 to 100 mol% trimethylene carbonate.