US 9,168,141 B2 · Medical prosthetic devices and implants having improved biocompatibility

Abstract

Disclosed are medical prosthetic device or medical implants which exhibit improved biocompatibility. The devices or implants include a metal material, e.g., titanium, in which the metal surfaces are coated with a corresponding hydride material that contains one or more biomolecule substance. The biomolecule substance may contain one or more biologically active molecules, e.g., bio-adhesives, biopolymers, blood proteins, enzymes, extracellular matrix proteins, extracellular matrix biomolecules, growth factors and hormones, peptide hormones, deoxyribonucleic acids, ribonucleic acids, receptors, inhibitors, drugs, biologically active anions and cations; vitamins; adenosine monophosphate (AMP), adenosine diphosphate (ADP) or adenosine triphosphate (ATP), marker biomolecules, amino acids, fatty acids, nucleotides (RNA and DNA bases), or sugars.

Claims24

Dependent claims

A method for preparing a medical prosthetic device or medical implant, said method comprising:

subjecting surface parts of a metal material selected from the group consisting of titanium or an alloy thereof, zirconium or an alloy thereof, tantalum or an alloy thereof, hafnium or an alloy thereof, niobium or an alloy thereof and a chromium-vanadium alloy to an electrolysis treatment in the presence of one or more biomolecule(s), said metal material constituting a cathode during said electrolysis, in which method a layer of a corresponding hydride material selected from the group consisting of titanium hydride, zirconium hydride, tantalum hydride, hafnium hydride, niobium hydride and chromium and/or vanadium hydride is formed on said surface parts and the biomolecule(s) become associated with the hydride material,
wherein the electrolysis treatment is carried out in the presence of an electrolyte comprising the one or more biomolecule(s) having a net positive charge in the electrolyte;
and
wherein the one or more biomolecule(s) is not collagen.

1 more element

Dependencies are inferred from the claim text.

Medical prosthetic devices and implants having improved biocompatibility

Life of this patent

Medical prosthetic devices and implants having improved biocompatibility

Life of this patent

Abstract

Claims24