Back to results
US 9,168,139 B2Granted
Vertical bone augmentation using endothelial progenitor cells
AssigneeHealth Corporation - Rambam
InventorsHadar Zigdon-Giladi, Dina Lewinson, Tova Bick, Eli Machtei
Life of this patent
Estimating the term…
Abstract
A method of facilitating augmentation of osseous tissue on a surface of a bone is disclosed. The method includes combining a scaffolding, an enclosure substantially enclosing the scaffolding relatively to the surface of the bone and a cell culture seeded onto the scaffolding.
Claims17
A method of facilitating augmentation of osseous tissue on a surface of a bone, said method comprising:
- (a) providing a scaffolding and a rigid enclosure;
- (b) preparing a surface of a bone for augmentation of osseous tissue, wherein said preparing comprising at least one of:
- exposing at least one portion of the surface where augmentation is desired;
- and performing a plurality of minute perforations in at least one cortical portion of said bone where augmentation is desired;
- (c) placing said scaffolding on the portions of said bone;
- (d) placing said rigid enclosure onto said scaffolding thereby enclosing said scaffolding relatively to the surface of said bone;
- (e) seeding cells on said scaffolding thereby obtaining a newly augmented osseous tissue on the surface of said bone wherein said cells are selected from at least one cell culture selected from the group consisting of:
- an early endothelial progenitor cell culture;
- an early mesenchymal stem cells culture;
- a late endothelial progenitor cell culture;
- a late mesenchymal stem cells culture;
- peripheral blood derived endothelial progenitor cells and mesenchymal stem cells.
9 more elements
A system for facilitating augmentation of osseous tissue on a surface of a bone, said system comprising:
- (a) a scaffolding adapted to be placed on a bone;
- (b) a rigid enclosure adapted to enclose said scaffolding;
- and
- (c) cells from at least one cell culture selected from the group consisting of:
- an early endothelial progenitor cell culture;
- an early mesenchymal stem cells culture;
- a late endothelial progenitor cell culture;
- a late mesenchymal stem cells culture;
- peripheral blood derived endothelial progenitor cells and mesenchymal stem cells, wherein said cells are seeded onto said scaffolding.
6 more elements
Dependencies are inferred from the claim text.