Aspirating implants and method of bony regeneration
AssigneeDePuy Synthes Products, Inc.
InventorsMichael J. O'Neil, Liesbeth Brown, Nimish Parikh, Daniel Keeley, Shannon Webster
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Abstract
Devices and methods for in situ drawing, filtering and seeding cells from the marrow of surrounding bone into a fusion cage without any of the challenges mentioned above. Various implants and devices with aspiration ports that enable in-situ harvesting and mixing of stem cells. These devices may include spinal fusion cages, long bone spacers, lateral grafts and joint replacement devices. Each device utilizes at least one aspiration port for harvesting of stem cell-containing marrow via aspiration from adjacent bony elements.
Claims22
An intervertebral fusion assembly, comprising:
- a) an intervertebral fusion cage, comprising:
- i) an upper surface adapted for gripping an upper vertebral body and comprising an upper throughole therethrough,
- ii) a lower surface adapted for gripping a lower vertebral body and comprising a lower throughole therethrough,
- iii) a sidewall connecting the upper and lower surfaces and comprising an aspiration port therethrough, and
- b) an aspirator,
- wherein the aspirator connects to the aspiration port to provide fluid connection between the fusion cage and the aspirator,
- wherein the aspiration port comprises a one-way valve that enables aspiration while preventing subsequent leakage,
- wherein at least one of the upper surface and lower surface includes a compressible seal lining its throughole.
An intervertebral fusion cage, comprising:
- a) an upper surface adapted for gripping an upper vertebral body and comprising an upper throughole therethrough,
- b) a lower surface adapted for gripping a lower vertebral body and comprising a lower throughole therethrough,
- c) a sidewall connecting the upper and lower surfaces and comprising an aspiration port therethrough, and
- d) at least one compressible endplate seal disposed about either the upper or lower throughhole,
- wherein the aspiration port comprises a one-way valve that enables aspiration while preventing subsequent leakage,
- wherein the seal lines the throughhole.
An interbody fusion assembly, comprising:
- a) an interbody fusion device, comprising:
- i) a housing comprising upper and lower endplates having upper and lower througholes therethrough,
- ii) a porous matrix contained with the housing,
- iii) an aspiration port therethrough, and
- b) an aspirator,
- wherein the aspirator connects to the aspiration port to provide fluid connection between the fusion device and the aspirator,
- wherein the aspiration port comprises a one-way valve that enables aspiration while preventing subsequent leakage,
- wherein at least one of the upper surface and lower surface includes a compressible seal surrounding the upper or lower throughhole.
Dependencies are inferred from the claim text.