Loading patent…
AssigneesCentro De Investigaciones Energeticas, Medioambientales Y Tecnologicas, Centro Comunitario de Transfusión de Asturias-Cruz Roja Espanola, Fundación Marcelino Botin
InventorsJose Luis Jorcano Noval, Fernando Larcher Laguzzi, Alvaro Meana Infiesta, Sara Gomez Llanes, Marcela Del Rio Nechaevsky
Estimating the term…
Artificial dermis (1) obtained from plasma with platelets (2) and human fibroblasts. The plasma with platelets (2) is obtained from the fractionating of total blood (4) from the patient (8) by light centrifugation, and the human fibroblasts (3) from a skin biopsy, (5). Clotting is obtained by adding calcium. This artificial dermis (1) permits rapid growth of the keratinocytes (6) seeded on its surface to build an artificial skin (7) which can easily be transplanted. Large areas of artificial dermis (1) are obtained from small amounts of starting materials and can be enriched with cytokines and platelet growth factors, to strengthen proliferation of the cells seeded. The artificial skin (7) obtained can be used to treat major burn treatments, chronic skin ulcers, etc., or be used, by employing genetically altered cells, as a vehicle for gene therapy.
An artificial skin comprising a matrix obtained by clotting human plasma-containing platelets and dermal cells, wherein platelets and dermal cells are embedded in the matrix, said artificial skin further comprising cultivated keratinocytes on a surface of the matrix, and wherein the artificial skin is suitable for transplantation.
An artificial skin comprising a matrix obtained by clotting human plasma containing platelets and dermal cells, wherein platelets and dermal cells are embedded in the matrix, said artificial skin further comprising cultivated keratinocytes on a surface of the matrix, wherein the artificial skin is suitable for transplantation, and, wherein the dermal cells are mesenchymal stem cells or endothelial cells.
A method of obtaining artificial skin, comprising the steps of:
Dependencies are inferred from the claim text.