Method and system for patient-specific modeling of blood flow
AssigneeHeartFlow, Inc.
InventorCharles A. Taylor
Life of this patent
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Abstract
Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.
Claims30
A method for non-invasive assessment of coronary artery stenosis, comprising:
- extracting patient-specific anatomical measurements of coronary arteries of a patient from medical image data of the patient;
- determining a model of coronary circulation comprising a reduced-order model that defines a blood pressure drop across at least one stenosis region of the coronary arteries of the patient as a function of blood flow velocity through the stenosis region;
- determining first patient-specific boundary conditions of the model of coronary circulation representing the coronary arteries using the patient-specific anatomical measurements and non-invasive clinical measurements of the patient;
- determining second patient-specific boundary conditions of the model of coronary circulation using the first patient-specific boundary conditions;
- simulating blood flow and pressure across the at least one stenosis region of at least one coronary artery using the model of coronary circulation and the second patient-specific boundary conditions;
- and
- determining a characteristic of blood flow through the at least one stenosis region using the simulated blood flow and pressure.
An apparatus comprising at least one computer system containing computer-executable programming instructions for performing a method for determining patient-specific cardiovascular information, the method comprising:
- extracting patient-specific anatomical measurements of coronary arteries of a patient from medical image data of the patient;
- determining a model of coronary circulation comprising a reduced-order model that defines a blood pressure drop across the at least one stenosis region as a function of blood flow velocity through the stenosis region;
- determining first patient-specific boundary conditions of the model of coronary circulation representing the coronary arteries using the patient-specific anatomical measurements and non-invasive clinical measurements of the patient;
- determining second patient-specific boundary conditions of the model of coronary circulation using the first patient-specific boundary conditions;
- simulating blood flow and pressure across the at least one stenosis region of at least one coronary artery using the model of coronary circulation and the second patient-specific boundary conditions;
- and
- determining a characteristic of blood flow through the at least one stenosis region using the simulated blood flow and pressure.
A non-transitory computer readable medium storing computer program instructions for non-invasive assessment of coronary artery stenosis, the computer program instructions when executed by a processor cause the processor to perform operations comprising:
- extracting patient-specific anatomical measurements of coronary arteries of a patient from medical image data of the patient;
- determining a model of coronary circulation comprising a reduced-order model that defines a blood pressure drop across the at least one stenosis region as a function of blood flow velocity through the stenosis region;
- determining first patient-specific boundary conditions of the model of coronary circulation representing the coronary arteries using the patient-specific anatomical measurements and non-invasive clinical measurements of the patient;
- determining second patient-specific boundary conditions of the model of coronary circulation using the first patient-specific boundary conditions;
- simulating blood flow and pressure across the at least one stenosis region of at least one coronary artery using the model of coronary circulation and the second patient-specific boundary conditions;
- and
- determining a characteristic of blood flow through the at least one stenosis region using the simulated blood flow and pressure.
A method for non-invasive assessment of coronary artery stenosis, comprising:
- extracting patient-specific anatomical measurements of the coronary arteries from medical image data of a patient acquired during a hyperemia state;
- determining a model of coronary circulation comprises a reduced-order model that defines a blood pressure drop across the at least one stenosis region as a function of blood flow velocity through the stenosis region;
- determining patient-specific hyperemic boundary conditions of the model of coronary circulation representing the coronary arteries using the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at hyperemia;
- simulating hyperemic blood flow and pressure across the at least one stenosis region of at least one coronary artery using the model of coronary circulation and the patient-specific hyperemic boundary conditions;
- and
- determining a characteristic of blood flow through the at least one stenosis region using the simulated hyperemic blood flow and pressure.
Dependencies are inferred from the claim text.