Adeno-associated virus 2/8—micro RNA-101 therapy for liver cancer
OwnerKoteswara Rao Kollipara, Ramesh Babu Batchuinventors
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Abstract
Adeno-associated virus 2/8-microRNA-101(AAV2/8-miR-101) therapy for liver cancer is provided. In particular, the invention provides a recombinant AAV 2/8 vector, comprising mutated capsid, for the enforced expression of pre-miR-101 and for the treatment of liver cancer.
Claims11
A vector for enforced expression of pre-miR-101 comprising a polynucleotide sequence of SEQ ID NO:1.
A cell line comprising a vector for enforced expression of pre-miR-101, wherein said vector comprises of a polynucleotide sequence of SEQ ID NO:
- 1.
A pharmaceutical composition for enforced expression of pre-miR-101 comprising:
- a vector of polynucleotide sequence of SEQ ID NO:
- 1;
- and a pharmaceutically acceptable carrier.
A method for enforced expression of pre-miR-101 comprising:
- administering to a subject a vector of polynucleotide sequence of SEQ ID NO:
- 1.
A method for treating a patient having a cancer, comprising:
- administering to a patient a therapeutically effective amount of a vector of polynucleotide sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.