Compositions and methods for binding lysophosphatidic acid
AssigneeLpath, Inc.
InventorsRoger A. Sabbadini, William A. Garland, Genevieve Hansen, James Stephen Swaney, Rosalia Matteo, Gordon Mills, Jonathan Michael Wojciak
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Abstract
Compositions and methods for making and using anti-LPA agents, for example, monoclonal antibodies, are described. Variable domain and complementarity determining region amino acid sequences of several monoclonal antibodies against LPA are disclosed, as is a consensus anti-LPA monoclonal antibody variable domain sequence.
Claims6
A diagnostic reagent comprising a derivatized lysophosphatidic acid (LPA) conjugated to a solid support or carrier, wherein the derivatized LPA is selected from the group consisting of 18:2, 18:1, 18:0, 16:0 and 20:4 LPA, and wherein the hydrocarbon chain of the derivatized LPA includes a reactive group at the most distal carbon position of the hydrocarbon chain.
Dependencies are inferred from the claim text.