Gold coated super paramagnetic iron oxide nano-particles (SPIONs) and a method of synthesizing the same
OwnerMorteza Mahmoudi, Mohammad Ali Shokrgozarinventors
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Abstract
The various embodiments herein provide a gold coated SPIONs with jagged surface. The gold coated SPIONs have a core and a shell. The core is a SPION molecule and the shell is a jagged gold layer. A non-uniform polymeric gap exists between the core and the shell. The embodiments also provide a method of producing the jagged gold coated SPIONs by mixing a colloidal dispersion of SPIONs with pH sensitive polymers. Adding a gold salt to the above mixture and reducing the gold salt to form jagged gold coated SPIONs.
Claims14
A gold coated super paramagnetic Iron oxide nano-particle (SPION) comprising;
- a core, and wherein the core includes a super paramagnetic Iron oxide nano-particle;
- a shell, and wherein the shell includes a jagged coating of gold;
- and
- a gap between the core and the shell, and wherein the gap is a polymeric gap, and wherein the gap is a non uniform gap, and wherein the gap includes a plurality of polymeric molecules, and wherein the plurality of polymeric molecules includes poly (2-vinyl pyridine), PL-PEG-COOH and Poly-L-histidine, and wherein the poly (2-vinyl pyridine) is a pH sensitive polymer, and wherein the poly (2-vinyl pyridine) controls a formation of jagged shaped gold surfaces,
- wherein poly (2-vinyl pyridine) has folded shape, and wherein PL-PEG-COOH has a stranded shape,
- wherein the gold coated SPIONS with a jagged surface conjugates with bio molecules to provide a nano probe for molecular diagnosis and cellular tracking, medical imaging and therapeutic applications, and molecular theragnosis, wherein therapeutic applications include a drug delivery and a simultaneous drug delivery and imaging application properties.
A method of synthesizing a gold coated super paramagnetic iron oxide nano-particle (SPION) comprising steps of:
- preparing a colloidal dispersion of SPIONS, wherein the colloidal dispersion of SPIONS is prepared by a chemical process;
- adding a plurality of polymers to form a mixture, wherein the plurality of polymers include a poly (2-vinyl pyridine) polymer and a PL-PEG-COOH polymer;
- heating the mixture to 80° C. for 5 mins;
- dispersing the heated mixture in DI water with sonication;
- adding a polymer to the dispersed and sonicated mixture to form an another mixture, wherein the polymer is a Poly-L-histidne polymer;
- adding a gold salt to the another mixture and mixing the another mixture with the added gold salt for 20 mins;
- adjusting a pH of the mixed another mixture with the added gold salt to 4-5, wherein the pH is adjusted using a NaOH solution;
- reducing the added gold salt;
- and
- acquiring the gold coated super paramagnetic iron oxide nano-particle (SPION) in a form of a solution, wherein the gold coating is jagged;
- and
- keeping the formed solution between 2-8° C. by re-dispersing in a deionized water using a sonicator.
Dependencies are inferred from the claim text.