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US 9,157,071 B2Granted
Herpes simplex virus (HSV) with modified tropism, uses and process of preparation thereof
AssigneeAlma Mater Studiorum - Università di Bologna
InventorsGabriella Campadelli, Laura Menotti
Life of this patent
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Abstract
A modified Herpes Simplex Virus (HSV), which has a portion of gD (glycoprotein D) of the glycoproteic envelope deleted and a heterologous single chain antibody inserted in place of such deleted portion; the modified HSV is capable of infecting cells through receptor HER2/ErbB2 but not through receptors HVEM/HveA and nectin1/HveC; uses of the modified HSV and a process of the preparation thereof are also disclosed.
Claims17
A modified herpes simplex virus (HSV) comprising a modified glycoprotein envelope;
- wherein said modified glycoprotein envelope comprises an altered HSV glycoprotein D (gD), wherein said gD has a portion deleted and a single chain antibody inserted thereto;
- wherein the deleted portion (i) starts at any of amino acid residue positions 1 to 8 and ends at any of amino acid residue positions 38 to 55, or (ii) starts at any of amino acid residue positions 40 to 61 and ends ay any of amino acid residue positions 210 to 218;
- wherein the positions of said residues corresponds to the residue numbering of SEQ ID NO:
- 1.
1 more element
Dependencies are inferred from the claim text.