Drug transporter permeating blood-brain barrier, peptide and use thereof
AssigneeMicrobial Chemistry Research Foundation
InventorsAkio Nomoto, Coh-ichi Nihei
Life of this patent
Estimating the term…
Abstract
A peptide, wherein the peptide comprises an amino acid sequence expressed by the following SEQ ID NO: 1, an amino acid sequence expressed by the following SEQ ID NO: 2, an amino acid sequence expressed by the following SEQ ID NO: 3, an amino acid sequence expressed by the following SEQ ID NO: 4, or any combination thereof: (SEQ ID NO: 1) ALGDSLYGAASLN; (SEQ ID NO: 2) MTVDNPASTTNKDKLFSVWK; (SEQ ID NO; 3) PGAVPEK; and (SEQ ID NO: 4) STKDLTTY.
Claims18
A peptide consisting of SEQ ID NO:
- 2.
A drug transporter comprising:
- a peptide consisting of SEQ ID NO:
- 2 and a carrier, wherein the carrier is a macromolecule, a microassembly, a microparticle, a microsphere, a nanosphere, a liposome or any combination thereof.
A blood-brain barrier permeating agent, comprising:
- a peptide consisting of SEQ ID NO:
- 2 and a carrier, wherein the carrier is a macromolecule, a microassembly, a microparticle, a microsphere, a nanosphere, a liposome, or any combination thereof, and
- wherein the blood-brain barrier permeating agent permeates blood-brain barrier.
A transferrin receptor capturing body, comprising:
- a peptide consisting of SEQ ID NO:
- 2 and a carrier, wherein the carrier is a macromolecule, a microassembly, a microparticle, a microsphere, a nanosphere, a liposome, or any combination thereof, and
- wherein the transferrin receptor capturing body binds to a transferrin receptor.
A drug transporter comprising:
- a peptide consisting of SEQ ID NO:
- 1 and a carrier,
- wherein the carrier is a microassembly, a microparticle, a microsphere, a nanosphere, a liposome, an emulsion, or any combination thereof.
A blood-brain barrier permeating agent, comprising:
- a peptide consisting of SEQ ID NO:
- 1 and a carrier,
- wherein the carrier is a microassembly, a microparticle, a microsphere, a nanosphere, a liposome, an emulsion, or any combination thereof, and
- wherein the blood-brain barrier permeating agent permeates blood-brain barrier.
A transferrin receptor capturing body, comprising:
- a peptide consisting of SEQ ID NO:
- 1 and a carrier,
- wherein the carrier is a macromolecule, a microassembly, a microparticle, a microsphere, a nanosphere, a liposome, an emulsion, or any combination thereof, and
- wherein the transferrin receptor capturing body binds to a transferrin receptor.
A drug transporter comprising:
- a peptide consisting of SEQ ID NO:
- 3 and a carrier, and
- wherein the carrier is a microassembly, a microparticle, a microsphere, a nanosphere, a liposome, or any combination thereof.
A blood-brain barrier permeating agent, comprising:
- a peptide consisting of SEQ ID NO:
- 3 and a carrier,
- wherein the carrier is a microassembly, a microparticle, a microsphere, a nanosphere, a liposome, or any combination thereof, and
- wherein the blood-brain barrier permeating agent permeates blood-brain barrier.
A transferrin receptor capturing body, comprising:
- a peptide consisting of SEQ ID NO:
- 3 and a carrier,
- wherein the carrier is a macromolecule, a microassembly, a microparticle, a microsphere, a nanosphere, a liposome, or any combination thereof and,
- wherein the transferrin receptor capturing body binds to a transferrin receptor.
A drug transporter comprising:
- a peptide consisting of SEQ ID NO:
- 4 and a carrier,
- wherein the carrier is a microassembly, a microparticle, a microsphere, a nanosphere, a liposome, an emulsion, or any combination thereof.
A blood-brain barrier permeating agent, comprising:
- a peptide consisting of SEQ ID NO:
- 4 and a carrier,
- wherein the carrier is a microassembly, a microparticle, a microsphere, a nanosphere, a liposome, an emulsion, or any combination thereof, and
- wherein the blood-brain barrier permeating agent permeates blood-brain barrier.
A transferrin receptor capturing body, comprising:
- a peptide consisting of SEQ ID NO:
- 4 and a carrier,
- wherein the carrier is a microassembly, a microparticle, a microsphere, a nanosphere, a liposome, an emulsion, or any combination thereof, and
- wherein the transferrin receptor capturing body binds to a transferrin receptor.
Dependencies are inferred from the claim text.