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US 9,156,786 B2Granted
Process to prepare treprostinil, the active ingredient in remodulin®
AssigneeUnited Therapeutics Corporation
InventorsHitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
Life of this patent
Estimating the term…
Abstract
This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.
Claims15
A process for preparing a pharmaceutical product comprising treprostinil or a treprostinil salt, comprising:
- combining treprostinil and a base in solution to form a base addition salt;
- allowing crystallization of the base addition salt of treprostinil;
- collecting the base addition salt of treprostinil, storing the collected base addition salt at ambient temperature, and preparing a pharmaceutical product comprising treprostinil or a treprostinil salt from the base addition salt after the storage.
Dependencies are inferred from the claim text.