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US 9,156,783 B2Granted
Compounds for treating proliferative disorders
AssigneeSynta Pharmaceuticals Corp.
InventorsShoujun Chen, Keizo Koya, Zachary Demko, Lijun Sun
Life of this patent
Estimating the term…
Abstract
Disclosed are compounds of formulae (I), (III), (IV), (VII), (X), (XI), (XII), (XIII) and (XIV), wherein the variables are as defined in the claims, and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.
Claims27
A compound represented by formula (I):
- or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein:
- R1 and R2 are independently an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, halo, nitro, cyano, guanidino, —OR17, —NR19R20, —C(O)R17, —C(O)OR17, —OC(O)R17, —C(O)N19R20, —NR18C(O)R17, —OP(O)(OR17)2, —SP(O)(OR17)2, —SR17, —S(O)pR17, —OS(O)pR17, —S(O)pOR17, —NR18S(O)pR17, or —S(O)pN19R20;
- R3 and R4 are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl or an optionally substituted heteroaryl;
- R5 and R6 are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl or an optionally substituted heteroaryl;
- R13 is a covalent bond, or a substituted or unsubstituted C1-C6 alkylene group;
- R17 and R18, for each occurrence, are, independently, —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
- R19 and R20, for each occurrence, are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
- or R19 and R20, taken together with the nitrogen to which they are attached, form an optionally substituted heterocyclyl or an optionally substituted heteroaryl;
- and
- p is 1 or 2;
- provided that when R13 is —CH2—, R3 and R4 are both phenyl and R5 and R6 are both —H, then R1 and R2 are not both phenyl;
- and
- provided that when R13 is —CH2—, R3 and R4 are both phenyl and R5 and R6 are both —H, then R1 and R2 are not both methyl.
10 more elements
A compound represented by formula (III) or (IV):
- or a tautomer, pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein:
- X1, X2, X3 and X4 are independently selected from the group consisting of
- Z1, Z2, Z3, and Z4 are each independently O or S;
- R1 and R2 are independently an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, halo, nitro, cyano, guanidino, —OR17, —NR19R20, —C(O)R17, —C(O)OR17, —OC(O)R17, —C(O)N19R20, —NR18C(O)R17, —OP(O)(OR17)2, —SP(O)(OR17)2, —SR17, —S(O)pR17, —OS(O)pR17, —S(O)pOR17, —NR18S(O)pR17, or —S(O)pN19R20;
- provided that for formula (III), R1 and R2 are not —OH, —SH, or —NH2;
- R3 and R4 are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl or an optionally substituted heteroaryl;
- and
- R5 and R6 are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl or an optionally substituted heteroaryl;
- R9, R10, and R11 are each independently —H, —NR19R20, halo, —OR17, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl or an optionally substituted heteroaryl;
- R13 is a covalent bond, or a substituted or unsubstituted C1-C6 alkylene group;
- R17 and R18, for each occurrence, are, independently, —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
- R19 and R20, for each occurrence, are independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
- or R19 and R20, taken together with the nitrogen to which they are attached, form an optionally substituted heterocyclyl or an optionally substituted heteroaryl;
- and
- p is 1or 2.
12 more elements
Dependencies are inferred from the claim text.