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AssigneeLianyungang Jinkang Hexin Pharmaceutical Co., Ltd.
InventorsZheqing Wang, Yongzhi Cheng, Heng Huang, Huizhen Li
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Disclosed are a crystal form of (6S)-5-methyltetrahydrofolate salt and a method for preparing the same. The crystal form is: Form C of the crystal form of (6S)-5-methyltetrahydrofolate calcium salt, where the X-ray diffraction pattern has diffraction peaks at the 2θ angles of 6.3±0.2 and 19.2±0.2; or the crystal form of (6S)-5-methyltetrahydrofolate strontium salt, where the X-ray diffraction pattern has diffraction peaks at the 2θ angles of 6.5±0.2 and 22.0±0.2. The crystal form of (6S)-5-methyltetrahydrofolate salt of the present invention has the advantages of excellent physicochemical properties, good stability, high purity, good reproducibility, and being more suitable for production on an industrial scale.
A crystal form of (6S)-5-methyltetrahydrofolate salt, wherein the crystal form is:
A method for preparing Form C of the crystal form of (6S)-5-methyltetrahydrofolate calcium salt having diffraction peaks at the 2θ angles of 3.2±0.2, 6.3±0.2, 13.2±0.2, 14.6±0.2, 19.2±0.2 and 32.6±0.2, wherein the Form C of (6S)-5-methyltetrahydrofolate calcium salt is crystallized from a polar medium, wherein the crystallization process comprises:
Dependencies are inferred from the claim text.