US 9,149,794 B2 · Formyl group-containing porous support, adsorbent using same, method for producing same, and method for producing the adsorbent

Abstract

The present invention relates to a method for producing a formyl group-containing porous base matrix, comprising the steps of introducing a spacer in a formyl group-containing porous particle; and then oxidizing the spacer with periodic acid and/or a periodate, to transform the part of the spacer into a formyl group; wherein the formyl group content in the porous particle after introduction of the spacer is not more than 3 μmol per 1 mL of the porous particle. Also, the present invention relates to a method for producing an adsorbent, comprising the step of immobilizing an amino group-containing ligand on the formyl group-containing porous base matrix. According to the present invention, a formyl-group containing porous base matrix and an adsorbent produced from the porous base matrix of which adsorption amount is high and which is has high strength and of which ligand is difficult to be leaked are provided.

Claims5

Dependent claims

A method for producing an affinity adsorbent, comprising the steps of

immobilizing an amino group-containing ligand on a formyl group-containing porous base matrix in two stages of imination and reductive reaction;
and
carrying out a stabilizing procedure after the imination and before adding a reducing agent for the reductive reaction,
wherein the imination is carried out in a reaction mixture having pH of not less than 11.5 and less than 13.0, and
the stabilizing procedure after the imination and before adding the reducing agent for the reductive reaction comprises adjusting a pH of a reaction mixture within ±1 of the pH during the reductive reaction without adding the reducing agent.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

13/266,773Filed 3 Dec 2009

Priority

JP 2008-3088933 Dec 2008

Published

US 2012/0108794 A13 May 2012

Granted

6 Oct 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

C08B 37/00
Preparation of polysaccharides not provided for in groups c08b1/00 - c08b35/00
B01J 20/289
Phases chemically bonded to a substrate, e.g. to silica or to polymers: bonded via a spacer
B01J 20/3212
Polymeric carriers, supports or substrates: consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon…
B01J 20/3219
Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond: involving a…

Formyl group-containing porous support, adsorbent using same, method for producing same, and method for producing the adsorbent

Life of this patent

Formyl group-containing porous support, adsorbent using same, method for producing same, and method for producing the adsorbent

Life of this patent

Abstract

Claims5