Compositions and methods for treatment of neoplastic disease
OwnerDavid Termaninventor
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Abstract
Herein we provide cDNA extracted from tumor cells, normal cells or treatment resistant tumor cells that have been transduced with virus capable of altering self and/or tumor associated antigens (VASTA) fused recombinantly to nucleic acids encoding wild type superantigens, superantigens, superantigen homologues and superantigen-tumor specific targeting molecules and further linked to a costimulatory molecule. The extracted cDNA is linked to a VASTA and delivered to tumor bearing hosts parenterally wherein they induce a tumoricidal response. These agents are also incorporated into a tumor tropic cell carrier for protected delivery to tumor.
Claims7
A method of treating a subject with a tumor comprising the steps of:
- (i) transducing a normal cell or a tumor cell of the same histologic type as said normal cell or a treatment resistant tumor cell of the same histologic type as said tumor cell with a virus or its genomic DNA, wherein said virus or said genomic DNA is operatively linked to nucleic acids encoding a superantigen, and
- (ii) extracting the DNA individually from each transduced tumor cell or normal cell or treatment resistant tumor cell encoding the superantigen and at least one self or tumor protein that has been altered in expression level or structure by the said virus or said superantigen, and
- (iii) incorporating less than 4000 base pairs of said individually extracted DNA into said virus or its genomic DNA, and
- (iv) administering to said subject parenterally by infusion or injection a tumoricidally effective amount of at least one of said viruses or said genomic DNA from at least one of said viruses, wherein said virus incorporates said extracted DNA and said genomic DNA incorporates said extracted DNA.
Dependencies are inferred from the claim text.