Cephem compound having catechol group

A compound of the formula:

• wherein,
• X is —N═, —CH═, —C(—R5)═, —C(—Br)═, or —C(—Cl)═;
• R5 is C1-8 alkyl or haloC1-8alkyl;
• W is —CH2—, —S— or —O—;
• U is —CH2—, —S— or —O— when W is —CH2—, or U is —CH2— when W is —S— or —O—;
• R1 and R2 are independently hydrogen, halogen, hydroxyl, carboxy, an optionally substituted C1-8 alkyl, an optionally substituted carbocyclic group, or an optionally substituted heterocyclic group;
• or
• R1 and R2 are taken together with an adjacent atom to form optionally substituted carbocyclic group or an optionally substituted heterocyclic group;
• R3 is hydrogen, —OCH3 or —NH—CH(═O);
• each R4 is independently hydrogen, halogen, hydroxyl, —CN, —C(═O)—R6, —C(═O)—OH,
• C1-8 alkyl, haloC1-8alkyl, or —OR6;
• k is an integer from 0 to 2;
• R6 is C1-8 alkyl or haloC1-8alkyl;
• m is an integer from 0 to 2;
• Q is a single bond, optionally substituted carbocyclic group, or an optionally substituted heterocyclic group;
• G is i) —C(═O)— or ii) a 5-membered heterocyclic group;
• wherein
• i) when G is —C(═O)—, then
• a) D is a single bond, —NH— or —R7—NH— wherein R7 is C1-8 alkylene;
• and E is optionally substituted cyclic group selected from the group consisting of formulae (1)-(3), (5)-(8), (10)-(11), (26)-(27) and (30)-(31) below, where the substituent group in the optionally substituted cyclic group for E is at least one group selected independently from the group consisting of optionally subsituted C1-8 alkyl or Substituent Group Alpha;
• or
• b) D is a group of following formula:
• wherein q is 0 or 1, and E is a group of following formula (46);
• and
• ii) when G is the 5-membered heterocyclic group;
• then
• D is —CH2— or —CH2—CH2—, and E is a group of following formula (10) in following cyclic groups of the moiety E:
• wherein, p is an integer from 1 to 3, n is 1 or 2, and Rx is optionally substitued C1-8 alkyl;
• provided that following compounds from (A-1) to (A-38) are excluded,
• and
• wherein the substituent group in each of the optionally substituted C1-8 alkyl, the optionally substituted carbocyclic group, and the optionally substituted heterocyclic group is at least one group selected independently from the Substituent Group Alpha,
• wherein the Substituent Group Alpha consists of halogen, hydroxy, C1-8 alkoxy, hydroxyC1-8alkoxy, C1-8 alkoxy C1-8 alkoxy, carboxy, amino, acylamino, C1-8 alkylamino, imino, hydroxyimino, C1-8 alkoxyimino, C1-8 alkylthio, carbamoyl, C1-8 alkylcarbamoyl, hydroxyC1-8alkylcarbamoyl, sulfamoyl, C1-8 alkylsulfamoyl, C1-8 alkylsulfinyl, cyano, nitro, a carbocyclic group, and a heterocyclic group,
• or an ester, which is formed at at least one site selected from the group consisting of a 4-position of a cephem skeleton and a 7-position thereof, a protected compound at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof.