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US 9,145,361 B2Granted
SDP-containing heterobifunctional agents
AssigneeLife Technologies Corporation
InventorsKyle Gee, Aimei Chen, Hee Chol Kang
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Abstract
The present disclosure is directed to a reactive ester agent for conjugating a click-reactive group to a carrier molecule or solid support. The reactive ester agent has the general formula IA, wherein the variables R1, R2, R3, Ra and L are described throughout the application.
Claims19
A compound of Formula IA or a salt thereof:
- wherein
- L is a linker,
- R1 is a halogen,
- R2 is a halogen,
- R3 comprises a water solubilizing group, and
- Ra is a click-reactive group selected from the group consisting of an alkyne reactive moiety, an azide reactive moiety, a diene, a dienophile, an epoxide or an aziridine compound.
3 more elements
A method of click-labeling a carrier molecule or solid support, said method comprising:
- contacting said carrier molecule or solid support comprising a nucleophilic group X and having the formula Rb—X with a compound of Formula IA or a salt thereof:
- wherein
- L is a linker,
- R1 is a halogen,
- R2 is a halogen,
- R3 comprises a water solubilizing group, and
- Ra is a click-reactive group selected from the group consisting of an alkyne reactive moiety, an azide reactive moiety, a diene, a dienophile, an epoxide or an aziridine compound;
- and
- forming a compound of Formula I or a salt thereof:
- wherein
- L is the linker,
- Ra is the click-reactive group, and
- Rb is the carrier molecule or solid support comprising the nucleophilic group X.
10 more elements
Dependencies are inferred from the claim text.