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US 9,140,706 B2Granted
Labeling reagents and methods of their use
AssigneeLife Technologies Corporation
InventorsEvan Antoulinakis, Kyle Gee, Aleksey Rukavishnikov
Life of this patent
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Abstract
The present disclosure is directed to a reactive ester agent capable of conjugating a reporter molecule to a carrier molecule or solid support. The reactive ester agent has the general formula: wherein the variables are described throughout the application.
Claims12
A compound of Formula IA or a tautomer or salt thereof:
- wherein,
- L is a linker;
- R1 is a halogen;
- R2 is a halogen;
- R3 is —COO−, —SO3−, substituted azenyl, PEG, phosphate, or bisphosphonate;
- and
- Ra is a reporter molecule.
4 more elements
A compound of Formula II or a tautomer or salt thereof:
- wherein,
- L is a linker;
- R1 is a halogen;
- R2 is a halogen;
- R3 is a water solubilizing group;
- R6, R7 and R9 are each independently selected from the group consisting of H, alkyl, substituted alkyl, alkoxy, substituted alkoxy, acyl, acylamino, acyloxy, amino, substituted amino, aminocarbonyl, aminothiocarbonyl, aminocarbonylamino, aminothiocarbonylamino, aminocarbonyloxy, aminosulfonyl, aminosulfonyloxy, aminosulfonylamino, amidino, carboxyl, carboxyl ester, (carboxyl ester)amino, (carboxyl ester)oxy, cyano, halo, hydroxy, nitro, SO3−, sulfonyl, substituted sulfonyl, sulfonyloxy, thioacyl, thiol, alkylthio, substituted alkylthio, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocyclyl, and substituted heterocyclyl;
- and
- n is 0, 1, or 2.
5 more elements
A compound selected from the group consisting of:
Dependencies are inferred from the claim text.