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US 9,139,835 B2Granted
Nucleic acid aptamers
AssigneeUniversity of Iowa Research Foundation
InventorsPaloma Giangrande, Francis Miller, William Thiel
Life of this patent
Estimating the term…
Abstract
The present invention relates to optimized aptamers and methods of using these aptamers.
Claims13
A nucleic acid molecule not more than 90 nucleotides in length comprising an aptamer, wherein the aptamer is aptamer-51 (SEQ ID NO:2373), aptamer-13 (SEQ ID NO:2335), aptamer-14 (SEQ ID NO:2336), aptamer-8 (SEQ ID NO:2330), aptamer-5 (SEQ ID NO:2327), aptamer-3 (SEQ ID NO:2325), aptamer-35 (SEQ ID NO:2366), aptamer-6 (SEQ ID NO:2328), or aptamer-11 (SEQ ID NO:2333).
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and
- (i) a nucleic acid molecule not more than 90 nucleotides in length comprising an aptamer, wherein the aptamer is aptamer-51 (SEQ ID NO:2373), aptamer-13 (SEQ ID NO:2335), aptamer-14 (SEQ ID NO:2336), aptamer-8 (SEQ ID NO:2330), aptamer-5 (SEQ ID NO:2327), aptamer-3 (SEQ ID NO:2325), aptamer-35 (SEQ ID NO:2366), aptamer-6 (SEQ ID NO:2328), or aptamer-11 (SEQ ID NO:2333);
- or
- (ii) conjugate comprising the a nucleic acid molecule not more than 90 nucleotides in length comprising an aptamer, wherein the aptamer is aptamer-51 (SEQ ID NO:2373), aptamer-13 (SEQ ID NO:2335), aptamer-14 (SEQ ID NO:2336), aptamer-8 (SEQ ID NO:2330), aptamer-5 (SEQ ID NO:2327), aptamer-2 (SEQ ID NO:2333), aptamer-3 (SEQ ID NO:2325), aptamer-35 (SEQ ID NO:2366), aptamer-6 (SEQ ID NO:2328), or aptamer-11 (SEQ ID NO:2333), linked to a therapeutic or diagnostic molecule.
Dependencies are inferred from the claim text.