Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use
AssigneeThe Trustees of the University of Pennsylvania
InventorsJames M Wilson, Guangping Gao, Soumitra Roy
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Abstract
A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
Claims12
A recombinant adenovirus having an adenovirus capsid comprising a SV25 hexon protein having the amino acid sequence of SEQ ID NO:34, said capsid having packaged therein a nucleic acid sequence comprising (a) an adenovirus 5′ inverted terminal repeat sequence, (b) a nucleotide sequence heterologous to SV25 encoding a therapeutic or immunogenic product operably linked to expression control sequences which direct transcription, translation, and/or expression thereof in a host cell, and (c) an adenovirus 3′ inverted terminal repeat sequence.
Dependencies are inferred from the claim text.