Heteroalkyl linked pyrimidine derivatives

A method of inhibiting one or more protein kinase(s) selected from the group consisting of CDK2, FLT3 and JAK2, the method including exposing the one or more protein kinase(s) and/or co-factor(s) thereof to an effective amount of a compound according to a compound of formula I:

• wherein:
• R1 and R2 are each independently selected from the group consisting of:
• H, halogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl, arylalkenyl, cycloalkylheteroalkyl, heterocycloalkylheteroalkyl, heteroarylheteroalkyl, arylheteroalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxyaryl, alkenyloxy, alkynyloxy, cycloalkylkoxy, heterocycloalkyloxy, aryloxy, arylalkyloxy, phenoxy, benzyloxy, heteroaryloxy, amino, alkylamino, aminoalkyl, acylamino, arylamino, sulfonylamino, sulfinylamino, —COOH, —COR3, —COOR3, —CONHR3, —NHCOR3, —NHCOOR3, —NHCONHR3, alkoxycarbonyl, alkylaminocarbonyl, sulfonyl, alkylsulfonyl, alkylsulfinyl, arylsulfonyl, arylsulfinyl, aminosulfonyl, —SR3, R4S(O)R6—, R4S(O)2R6—, R4C(O)N(R5)R6—, R4SO2N(R5)R6—, R4N(R5)C(O)R6—, R4N(R5)SO2R6—, R4N(R5)C(O)N(R5)R6— and acyl, each of which may be optionally substituted;
• each R3, R4, and R5 is independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl and acyl, each of which may be optionally substituted;
• each R6 is independently selected from the group consisting of a bond, alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl and acyl, each of which may be optionally substituted;
• Z2 is selected from the group consisting of a bond, O, S, —N(R7)—, —N(R7)C1-2alkyl-, and —C1-2alkylN(R7)—;
• each R7 is independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, haloalkyl, hetero alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl and acyl, each of which may be optionally substituted;
• Ar1 and Ar2 are independently selected from the group consisting of aryl and heteroaryl, each of which may be optionally substituted;
• L is a group of formula:
• —X1—Y—X2—
• wherein X1 is attached to Ar1 and X2 is attached to Ar2, and wherein X1, X2 and Y are selected such that the group L has between 5 and 15 atoms in the normal chain,
• X1 and X2 are each independently an optionally substituted heteroalkyl group such that X1 and X2 are not both heteroalkyl groups containing at least one oxygen atom in the normal chain,
• Y is a group of formula —CRa═CRb- or an optionally substituted cycloalkyl group,
• wherein Ra and Rb are each independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl and acyl, each of which may be optionally substituted, or
• Ra and Rb may be joined such that when taken together with the carbon atoms to which they are attached they form a cycloalkenyl or cycloheteroalkenyl group;
• or a pharmaceutically acceptable salt, or N-oxide, thereof.