Amide compounds, compositions and uses thereof

A compound having a formula 2a:

• wherein
• X′ is CR4a;
• R1 is selected from unsubstituted pyrrolidinyl, unsubstituted piperidinyl, unsubstituted morpholinyl, unsubstituted thiomorpholinyl, unsubstituted 1,1-dioxo-thiomorpholinyl, unsubstituted piperazinyl, and unsubstituted azepinyl;
• or
• R1 is selected from pyrrolidinyl, piperidinyl, morpholinyl, thiomorpholinyl, piperazinyl, and azepinyl, each substituted with oxo;
• or
• R1 is Et, i-Pr, or t-Bu;
• each of R2a and R2b is independently selected from hydrogen, C1-C4 alkyl, hydroxyalkyl, alkoxyalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, haloalkyl, and halo;
• or R2a and R2b join together to form a cycloalkyl or heterocycloalkyl ring of 3-7 atoms;
• R3 is substituted or unsubstituted 6-10 membered aryl;
• each R4a, and R4b is independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted acyl, substituted or unsubstituted acylamino, substituted or unsubstituted alkylamino, substituted or unsubstituted alkythio, substituted or unsubstituted alkoxy, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted alkylarylamino, substituted or unsubstituted arylalkyloxy, substituted or unsubstituted amino, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, sulfo, substituted sulfo, substituted sulfonyl, substituted sulfinyl, substituted sulfanyl, substituted or unsubstituted aminosulfonyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted arylsulfonyl, azido, substituted or unsubstituted carbamoyl, carboxyl, cyano, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted dialkylamino, halo, heteroaryloxy, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroalkyl, hydroxy, nitro, and thiol;
• subscript m′ is selected from 0-4;
• and the subscript n2 is 0 or 1;
• or a pharmaceutically acceptable salt, solvate, stereoisomer or tautomer thereof.