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US 9,133,073 B2Granted
Compounds for the treatment of metabolic disorders
AssigneeWellstat Therapeutics Corporation
InventorShalini Sharma
Life of this patent
Estimating the term…
Abstract
Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
Claims5
A process for producing a compound of the formula:
- wherein R6 is alkyl having from 1 to 7 carbon atoms;
- n is 1 or 2;
- t is 0 or 1;
- and
- A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from:
- halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy;
- or
- cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono-substituted by methyl or ethyl;
- or
- a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound by a ring carbon,
- comprising, reacting a compound of the formula:
- with a compound of the formula BrCH2CO2R6 in the presence of a base, wherein R6, n, t and A are as above, to yield the corresponding compound of formula XI.
9 more elements
A process for producing a compound of the formula:
- wherein R5 is alkyl having from 1 to 3 carbon atoms;
- R6 is alkyl having from 1 to 7 carbon atoms;
- n is 1 or 2;
- t is 0 or 1;
- and
- A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from:
- halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy;
- or
- cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono-substituted by methyl or ethyl;
- or
- a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound by a ring carbon,
- comprising, reacting a compound of the formula:
- with a compound of the formula BrCH2CO2R6 in the presence of an alkali metal silyl amide, wherein R6, n, t and A are as above, to yield the corresponding compound of formula XXV.
10 more elements
A process for producing a compound of the formula:
- wherein n is 1 or 2;
- t is 0 or 1;
- and
- A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from:
- halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy;
- or
- cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono-substituted by methyl or ethyl;
- or
- a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound by a ring carbon,
- comprising, reacting a compound of the formula:
- with the sodium salt of diethylacetamidomalonate, wherein n, t and A are as above, to yield the corresponding compound of formula XXVIII.
8 more elements
Dependencies are inferred from the claim text.