Methods and systems for determining a transformation function to automatically register different modality medical images

A system comprising:

• a feature-image generator configured to analyze an input image to generate a first feature image, the input image including a region of interest (ROI) of an individual and being a medical image acquired by a first imaging modality, wherein the first feature image includes a designated anatomical feature of the ROI;
• a storage system configured to store an anatomical atlas, the atlas including a reference image of the ROI of at least one other individual and an organ model, the reference image being a medical image acquired by a second imaging modality that is different from the first imaging modality;
• and
• a transformation module configured to determine a transformation function by registering the first feature image with a second feature image that is based on the reference image and includes the designated anatomical feature;
• a registration module configured to apply the transformation function to the organ model to generate a registered organ model;
• and
• an analysis module configured to obtain a final organ position of an organ within the ROI and use the final organ position of the organ in the ROI to at least one of (a) automatically identify lesion types based on the final organ position;
• (b) generate one or more seed regions to segment the organ;
• or (c) identify a representative re ion in the organ and automatically calculate measurements of the organ in the representative region.