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US 9,126,914 B1Granted
Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone
AssigneeLonza Ltd.
InventorsFlorencio Zaragoza Doerwald, Anna Kulesza, Stephan Elzner, Robert Bujok, Zbigniew Wrobel, Krzysztof Wojciechowski
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Abstract
The invention discloses a method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal starting from 1-bromo 2,3-dimethylbenzene and chloroacetone, its use in perfumes and its use for the preparation of medetomidine.
Claims6
A method for the preparation of a compound of formula (XXI):
- the method comprises two steps, the two steps are a step (Q1) and a step (Q2);
- step (Q1) comprises a reaction (Q1-reac);
- reaction (Q1-reac) is a reaction of a compound of formula (XXV) with a reagent (Q1-reag) to provide a reaction product of reaction (Q1-reac);
- R1 is Br, Cl, or I;
- reagent (Q1-reag) is selected from the group consisting of lithium, magnesium, aluminum, zinc, calcium, propylmagnesium chloride, propylmagnesium bromide, butyllithium and mixtures thereof;
- step (Q2) comprises a reaction (Q2-reac);
- reaction (Q2-reac) is a reaction of the reaction product of reaction (Q1-reac) with chloroacetone to provide a reaction product of reaction (Q2-reac);
- the reaction product of reaction (Q2-reac) is a compound of formula (XXII);
- which is converted to a compound of formula (XXI).
6 more elements
Dependencies are inferred from the claim text.